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KMID : 1156220190450010062
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Journal of Environmental Health Sciences
2019 Volume.45 No. 1 p.62 ~ p.70
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Antioxidative Effect of Typha orientalis L. Extract on the Oxidative Stress Induced by Cytotoxicity of Cadmium Sulfate
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Yoon Ki-Chul
Sohn Young-Woo
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Abstract
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Objectives: This study was carried out to analyze the cytotoxicity of cadmium sulfate (CdSO 4 ) and the antioxidative effect of Typha orientalis L. (TO) extract on the oxidative stress induced by cytotoxicity of CdSO 4 in the cultured NIH3T3 fibroblasts.
Methods: For this study, the cell viability and the antioxidative effects such as the inhibitory activity of lipid peroxidation (LP) and superoxide dismutase (SOD)-like activity and xanthine oxidase (XO)-inhibitory activity were assessed.
Results: The cadmium sulfate significantly decreased cell viability in dose-dependently, and XTT 50 value was measured at 47.4 μM of CdSO 4 . The cytotoxicity of CdSO 4 was determined as highly toxic by Borenfreund and Puerner's toxic criteria. The butylated hydroxytoluene (BHT) as antioxidant significantly increased cell viability injured by CdSO 4 -induced cytotoxicity in these cultures. In the protective effect of TO extract on CdSO 4 -induced cytotoxicity, TO extract remarkably increased the inhibitory ability of LP and XO as well as SOD-like ability.
Conclusions: From the above results, it is suggested that the oxidative stress is involved in the cytotoxicity of CdSO 4 , and TO extract effectively protected CdSO 4 -induced cytotoxicity by antioxidative effects. The natural component like TO extract may be a putative therapeutic agent for treatment of the toxicity induced by heavy metallic compound like CdSO 4 correlated with the oxidative stress.
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KEYWORD
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Oxidative stress, heavy metallic compound, antioxidative effects
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